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| Poster #107 Semaglutide decreases hedonic eating in female rats with a history of binge eating. |
| Daniel /M Gaines, Lisa/ A Eckel, Jamila Guard Florida State University, Tallahassee, FL, United States |
Semaglutide (SEMA) is effective in decreasing caloric intake, leading to weight loss in individuals with obesity. Less is known about its ability to decrease binge eating in individuals with bulimic syndromes. Here, we tested the hypothesis that SEMA would decrease the overconsumption of calories in a rodent model of binge-like eating. To induce binge eating, female rats were maintained on chow and given intermittent access to high fat diet (HFD) at 4-day intervals (INT group). Control groups had free access to chow or chow and HFD (CHOW and HFD groups). Within these diet groups, rats received daily injections of SEMA (70 mg/kg) or vehicle. We further assessed SEMA’s ability to decrease hedonic eating in a 30-min chocolate Ensure “dessert” test, administered immediately after the consumption of a satiating meal. During the binge eating phase of the study, SEMA decreased cumulative food intake in INT and HFD groups, but not the CHOW group. When HFD was available, INT rats consumed 30-40% more calories than control groups (i.e., binged) during the first 2h of the dark phase. SEMA suppressed caloric intake during this 2-h period by ~20% in INT animals, but had no impact on food intake in HFD or CHOW animals at this timepoint. During the dessert test, SEMA decreased chocolate Ensure intake by 20-25% in INT rats but had no effect in CHOW or HFD rats. SEMA was also more effective in decreasing fat mass by over 50% (assessed via EchoMRI) in HFD and INT rats, but not CHOW rats We conclude that SEMA decreases hedonic eating in female rats with prior, intermittent exposure to HFD. Ongoing analyses are examining whether these effects of SEMA are mediated by its ability to increase meal-stimulated satiation signals. |