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| Poster #203 Persistent chemosensory dysfunction after COVID-19 and its associations with quality of life and eating behaviour: The COVORTS study |
| Birgit van Dijk & Sanne Boesveldt 1Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, --, Netherlands |
Knowledge on how persistent COVID-19-related chemosensory dysfunction affects quality of life and eating behaviour over time is lacking. The COVORTS cohort included 76 patients within 3 months of COVID-19 infection who self-reported smell dysfunction >1 month. For one year, patients filled in monthly questionnaires on quality of life, eating behaviour and self-reported chemosensory function, and olfactory and gustatory function was psychophysically measured every three months. The first aim of this analysis was to assess whether the associations between quality of life, eating behaviour and measures of chemosensory function change over time. The second aim was to evaluate whether it is possible to predict patients’ quality of life and eating behaviour at 1-year follow-up based on the measures taken at baseline. Quality of life was measured by the English olfactory disorders questionnaire (eODQ). Appetite and hunger ratings were measured by the Appetite, Hunger, and Sensory Perception questionnaire (AHSP). Using best subsets regression, we observed that both psychophysical and self-reported measures of chemosensory dysfunction were common predictors of our outcome measures, and that those predictors change between baseline and 1-year follow-up. For example, total Sniffin’ Sticks score and self-reported trigeminal functioning were common predictors for one of the eODQ outcomes at baseline, but no longer at 1-year follow-up. Instead, the Identification dimension of the Sniffin’ Sticks and parosmia were common predictors. These results will next be used to create a prediction model for the outcome measures at 1-year follow-up, based on the measurements collected at baseline. The results of this study will provide further insight in the burden of persistent COVID-19-related chemosensory dysfunction. |