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| Poster #205 Relation between olfactory cleft findings and pH in olfactory dysfunction patients |
| Rumi Sekine1,2, Eri Mori2, Yuji Kishimoto2, Monami Nagai2, Masayoshi Tei2,3, HIrotaka Tanaka2,4, Nobuyoshi Otori2 11. Department of Otorhinolaryngology, St. Luke’s International Hospital,, Tokyo, --, Japan 22. Department of Otorhinolaryngology, The Jikei University Hospital, Tokyo, --, Japan 33. Department of Otorhinolaryngology, The Jikei University Katsushika Medical Center, Tokyo, --, Japan 44. Department of Otorhinolaryngology, The Jikei University Kashiwa Hospital,, Chiba, --, Japan |
Background: Olfactory dysfunction (OD) can arise from aging, chronic sinusitis (CRS), and other factors affecting the olfactory cleft (OC) homeostasis. We have investigated that OD patients have significantly higher OC pH than normal subjects, suggesting that OC homeostasis is disrupted in patients. This study aims to investigate the factors associated with the change in OC pH including CT findings. Methods: We recruited patients with subjective OD, conducting general medical history taking, card type odour identification tests (OE), T&T olfactometry, general ENT examination and sinus CT scans. OC opacity was scored (0–5) by every 25 percent, and the Lund-Mackay (LM) scores of ethmoidal sinuses were recorded. Finally, a digital pH sensor catheter was placed at OC, middle turbinate (MT), middle meatus (MM) and each pH were recorded. Statistical significance was determined by Spearman’s rho (p<.05). Results: Among 50 patients (20 CRS-OD, Others ; 20 PVOD 8 PTOD, 2 idiopathic), OC pH correlated with MT/MM pH in CRS-OD and Others (p<0. 001), age and OD severity was also correlated in CRS-OD (Age ρ=36, p=0. 021, OE ρ=-0.41, p=0.015; T&T threshold ρ=0.39, p=0.21; VAS ρ=-0.65, p<0. 001), but not with Others (Age ρ=-0.21, p=0.374, OE ρ=-0.11, p=0.421; T& T threshold ρ=-0.03, p=0.838; VAS ρ=-0.23, p=0.084). Neither OC opacity nor LM scores correlated with pH or OD severity in both CRS-OD and Others. Conclusions: This study showed that CT findings were not related to OC pH, which was contrary to our expectations. However, elevated OC pH was significantly associated with severity of OD with CRS, highlighting the role of OC environmental damage in conductive OD. These results suggest that mucus components or some other different condition in the OC might play a critical role in OD, warranting further investigation. |