Presentation Details
Glomerular Sequence Represents Odor Quality in the Mouse Olfactory Bulb

Joshua S Harvey1, Khristina Samoilova2, Hiro Nakayama1, Farhad Pashakhanloo2, Alexei Koulakov2, Dmitry Rinberg1.

1Neuroscience Institute, New York University Langone Health, New York, NY, USA.2Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA

Abstract


Understanding how odor space is constructed by the olfactory system will allow us to decode olfactory information from neural recordings, and align representations across multiple animals. Here, we compare odor identity (quality) spaces constructed from both neural recordings and perceptual judgments obtained in mice. Using wide-field calcium imaging to monitor olfactory sensory neurons in the mouse olfactory bulb, we obtain spatio-temporal patterns of glomerular activity in response to 24 odors. We find glomerular sequence rank correlation provides a distance metric by which a concentration-invariant odor identity space can be constructed, allowing cross-concentration odor decoding with low-dimensional embeddings. In addition to rank correlation, we explore odor spaces constructed by overlaps in primacy sets of glomeruli, i.e. those activated early in the sniff cycle. We find rank correlation and primacy sets construct similar spaces, indicating the information richness of the early part of glomerular sequences. We show the rank correlation metric enables the alignment of odor representations across animals, and explore cross-animal alignment using a subset of anchor odors. We develop a heuristic that reliably predicts which subsets of odors are optimal anchors, providing the best alignment performance. Finally, we explored the relationship between neural and perceptual spaces, measuring perceptual distances in 10 mice with a delayed match-to-sample behavioral paradigm. We find perceptual space can be aligned to neural space, allowing for accurate odor decoding. Overall, we show that odor identity is represented by a common low-dimensional manifold, for both neural responses and odor percepts, suggesting that odor similarity relationships are preserved from sensory transduction through perception.

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