Conference Program

Welcome! Please find the current preliminary program for AChemS 2024 listed below. Note that any aspect of this program is subject to change.

April 17 (10:00 AM - 4:00 PM): Pre-Meeting
April 17-20: AChemS Annual Meeting Program

Wed - Apr 22

Thu - Apr 23

Fri - Apr 24

Sat - Apr 25

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THURSDAY, APRIL 23

7:30 - 9:00 AM BREAKFAST

BREAKFAST WITH INDUSTRY Pavilion/ Pavilion Lawn dsm-firmenich We are dsm-firmenich, committed to bringing progress to life by combining what is essential, desirable, and sustainable. We operate where these forces intersect, balancing individual needs, collective requirements, and planetary demands. Our purpose is to create essential products for life, desirable choices for consumers, and more sustainable solutions for people and planet. Visit our table to learn about the range of research careers available to industry scientists in fields including receptor biology, neuroscience, microbiome & hygiene, psychophysics, materials science, chemistry, and technical product development.

8:00 - 10:00 AM POSTER SESSION

POSTER SESSION I (click to view) (click to close) Pavilion

BUDS & CELLS

100

TASTE CODING FROM THE PERSPECTIVE OF A SINGLE TASTE BUD Syed A Uddin, Hanna Rodriguez, Thirada Boonrawd, Hojoon Lee. Northwestern University, Evanston, IL, USA

102

UTILIZING THE HTR3A-FLPO MOUSE LINE TO DEFINE GUSTATORY NEURON INNERVATION OF TYPE III TASTE BUD CELLS Ngozi Eze, Robin Krimm. University of Louisville, Louisville, KY

104

CHARACTERIZATION OF THE PERIPHERAL TASTE RECEPTOR CELLS IN PIGS Alison Duncan, Kathryn Medler. School of Animal Sciences, Virginia Tech, Blacksburg, VA, USA

106

ACE2 IS ENDOGENOUSLY EXPRESSED IN TASTE BUDS AND ITS CONDITIONAL DELETION FROM THE LINGUAL EPITHELIUM RESULTS IN ENHANCED NEURAL RESPONSES Emma Heisey1, Guangkuo Dong2, Yonggang Bao1, Hongyan Xu3, Lin Gan1, Lynnette McCluskey1. 1Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA. 2Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 3School of Public Health, Department of Biostatistics, Data Science and Epidemiology Medical College of Georgia, Augusta University, Augusta, GA, USA

108

INVESTIGATING AXONAL TRANSLATION AT ORAL SENSORY NERVE TERMINALS REVEALS A NOVEL ROLE FOR FGF13 IN TASTE BUD INNERVATION AND MAINTENANCE Debarghya Dutta Banik, Brian Pierchala. Department of Anatomy, Cell Biology a Physiology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA

110

ROLES OF HEDGEHOG CO-RECEPTOR GAS1 DURING POSTNATAL TASTE ORGAN DEVELOPMENT Gabrielle C. Audu1, Ashlyn P. McClelland1, Aysenur Sen2, Alvaro Garcia-Blanco1, Archana Kumari1. 1Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA. 2Rowan University, Glassboro, NJ, USA

112

DEVELOPING VON EBNER'S GLANDS IN EMBRYOS ARE THE MAIN SOURCE OF SOX10⁺ PROGENITORS FOR TASTE BUDS IN POSTNATAL MICE Md Mamunur Rashid, Yufei Huan, Hong-Xiang Liu. Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, USA

114

AUTOMATED 3D TRACKING OF TASTE BUD CELLS FOR MORPHOLOGICAL & LIFESPAN ANALYSIS Brittany N. Walters, David C. Alston, Robin F. Krimm. University of Louisville School of Medicine, Louisville, KY, USA

CORTEX

116

ODOR-EVOKED EXPECTATION IN GUSTATORY CORTEX MULTIPLEXES TASTE IDENTITY AND LICK DIRECTION Allison George, Alfredo Fontanini. Stony Brook University, Stony Brook, NY, USA

118

FUNCTIONAL RELEVANCE OF LINEAR AND CATEGORICAL CODING UNITS FOR TASTE MIXTURE-BASED DECISION-MAKING Liam Lang1, 2, 4, Camelia Yuejiao Zheng1, 2, 3, 4, Jennifer M Blackwell1, 4, Giancarlo La Camera1, 2, 4, Alfredo Fontanini1, 2, 3, 4. 1Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, USA. 2Graduate Program in Neuroscience, Stony Brook University, Stony Brook, NY, USA. 3Medical Scientist Training Program, Stony Brook University, Stony Brook, NY, USA. 4Center for Neural Circuit Dynamics, Stony Brook University, Stony Brook, NY, USA

120

PREMOTOR CONTROL OF PREPARATORY ACTIVITY IN THE GUSTATORY CORTEX John Chen1, Elyse Brozost1, 2, Alfredo Fontanini1, 2. 1Department of Neurobiology and Behavior, Stony Brook, NY, USA. 2Program in Neuroscience, Stony Brook, NY, USA

OLFACTORY BULB

122

OLFACTORY BULB GAMMA OSCILLATIONS MAY REPRESENT A VALENCE SCAFFOLD FOR THE NEXT SNIFF Frans Norden1, Anja L. Winter1, Mikael Lundqvist1, Artin Arshamian1, Johan N. Lundstrom1, 2, 3. 1Department of Clinical Neuroscience, Stockholm, Sweden. 2Monell Chemical Senses Center, Philadelphia, PA, USA. 3Department of Otorhinolaryngology, Stockholm, Sweden

124

ASSESSING THE MORPHOLOGICAL AND ELECTROPHYSIOLOGICAL SUBSTRATES OF EXPERIENCE-DEPENDENT PLASTICITY IN ACCESSORY OLFACTORY BULB INTERNEURONS Kazi Samanta Jerin1, Julian P. Meeks1, 2. 1Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA. 2Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA

126

MEASURING HUMAN OLFACTORY BULB GAMMA ON THE SINGLE BREATH LEVEL Adam Dede1, Qiohan Yang1, Andrew Sheriff1, Naelly Arriaga1, Aditi Agarwal2, Sajel Peters2, Gregory Lane1, Justin Morgenthaler1, Christina Zelano1, Bruce Tan2. 1Northwestern University Department of Neurology, Chicago, IL, USA. 2Feinberg School of Medicine Department of Otolaryngology-Head a Neck Surgery, Chicago, IL, USA

128

DYNAMICS OF NEURAL OSCILLATIONS IN THE OLFACTORY BULB RELATED TO TASK DEMANDS Andrew Sheriff1, Gregory Lane1, Qiaohan Yang1, Adam Dede1, Naelly Arriaga1, Bruce K. Tan2, Leslie M. Kay3, 4, Christina Zelano1. 1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 2Department of Otolaryngology - Head a Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 3Department of Psychology, The University of Chicago, Chicago, IL, USA. 4Institute for Mind and Biology, The University of Chicago, Chicago, IL, USA

130

HIGH-RESOLUTION MRI OF LAMINAR STRUCTURES IN THE HUMAN OLFACTORY BULB IN VIVO Jun Hua1, 2. 1F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. 2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

132

BEYOND BOLD: UNLOCKING HUMAN OLFACTORY BULB FUNCTION WITH ASL PERFUSION IMAGING Ludwig Sichen Zhao1, 2, Manuel Taso3, M. Dylan Tisdall3, John A. Detre2, 3, Jay A. Gottfried2, 4. 1Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA. 2Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 3Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 4Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA

134

ENHANCED MULTISENSORY INTEGRATION IN THE OLFACTORY BULB OF ASTYANAX MEXICANUS Evan Lloyd, Anna Koga, Sophia Ford, Douglas Storace. Florida State University, Tallahassee, FL, USA

136

RECEPTOR-DEFINED LATERAL INHIBITION IN THE MAMMALIAN OLFACTORY BULB Madison A. Herrboldt, Matt Wachowiak. University of Utah, Salt Lake Cty, UT, USA

138

IN VIVO DYNAMICS OF DOPAMINERGIC CIRCUITS IN THE MOUSE OLFACTORY BULB Priscilla Ambrosi, Abigail O'Niel, Elizabeth Moss. Oregon Health a Science University, Portland, OR, USA

140

DEFINING CD11B-DEPENDENT GLIAL PHAGOCYTOSIS AND GENE EXPRESSION CHANGES AFTER OLFACTORY INJURY David O. Poore, Diego J. Rodriguez-Gil. East Tennessee State University, Johnson CIty, TN, USA

142

NOGGIN BONKS AND NEUROGENESIS: ALTERATIONS IN OLFACTORY BULB ADULT NEUROGENESIS FOLLOWING A MOUSE MODEL OF TBI Tuesday Kirby Kahl1, 2, Priscilla Ambrosi1, Cory Butler1, Elizabeth Moss1. 1Oregon Health Sciences University, Portland, OR, USA. 2Portland State University, Portland, OR, USA

144

USING TARGETED RECOMBINATION IN ACTIVE POPULATIONS (TRAP), 2-PHOTON CALCIUM IMAGING, AND METABOLIC MONITORING TO INVESTIGATE THE EFFECT OF ADMINISTRATION OF THE GLUCAGON-LIKE PEPTIDE 1 (GLP-1) AGONIST SEMAGLUTIDE IN MICE. Debra A Fadool1, 2, 3, Madison A Herrboldt4, Saptarsi Mitra1, 3, Giorgio Belperio1, 3, Dale M Wachowiak4. 1Program in Neuroscience, Florida State University, Tallahassee, FL, USA. 2Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA. 3Biological Science Department, Florida State University, Tallahassee, FL, USA. 4Department of Neuroscience, University of Utah, Salt Lake City, UT, USA

OLFACTORY CODING

146

A QUANTITATIVE PERCEPTUAL FRAMEWORK FOR RECONSTRUCTING COMPLEX FOOD ODORS Xuebo Song1, Christiane Danilo1, Robert Pellegrino1, Joel Mainland1, 2. 11Monell Chemical Senses Center, Philadelphia, PA, USA. 22Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA

148

BEHAVIORAL STATE AND ETHOLOGICAL SALIENCE SHAPE HDB CHOLINERGIC ACTIVITY DURING NATURALISTIC OLFACTORY EXPLORATION Kelsey R. Glasper, Max L. Fletcher. University of Tennessee Health Science Center, Memphis, TN, USA

150

CHOICE SIGNALS EMERGE IN MOUSE PIRIFORM CORTEX DURING DELAYED OLFACTORY DECISION MAKING Srividya Pattisapu, Braden Brinkman, Alfredo Fontanini. Stony Brook University, Stony Brook, NY, USA

152

TIME-COURSE OF ODOR CODING IN THE HUMAN BRAIN - A SINGLE-NEURON PERSPECTIVE G. Naz Dikecligil1, Marcel S. Kehl2, Jay A. Gottfried1, Florian Mormann3. 1University of Pennsylvania, Philadelphia, PA, USA. 2University of Oxford, Oxford, United Kingdom. 3University of Bonn Medical Center, Bonn, Germany

154

POPULATION-LEVEL VARIATION IN OLFACTORY RECEPTOR TUNING IN DROSOPHILA MOJAVENSIS Dilini Karunappuli Herath Mudiyanselage, John E. Layne, Stephanie M. Rollmann. University of Cincinnati, Cincinnati, OH, USA

156

SPATIOTEMPORAL DYNAMICS OF ODOR FEATURE PROCESSING IN THE HUMAN BRAIN Sarah Cormiea, Naz Dikecligil, Joel Stein, Isaac Chen, Kathryn Davis, Jay Gottfried. University of Pennsylvania, Philadelphia, PA, USA

158

ACCESSORY OLFACTORY BULB MITRAL CELL REPRESENTATIONS OF NATURALISTIC SOCIAL ODORS ACROSS STIMULUS INTENSITY, SEX, AND CELLULAR COMPARTMENTS Kevin Y Gonzalez-Velandia, Tomas Aviles-Tamariz, Julian Meeks. Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

160

EXAMINING THE NEURAL REPRESENTATIONS UNDERLYING ODOR-GUIDED BEHAVIOR IN HUMANS Jared Newell, Liam McMahon, Xiaolin Qiao, James D Howard. Brandeis University, Waltham, MA, USA

162

EVIDENCE THAT INTERGLOMERULAR INHIBITION GENERATES NON-MONOTONIC CONCENTRATION-RESPONSE RELATIONSHIPS IN MITRAL/TUFTED GLOMERULI IN THE MOUSE OLFACTORY BULB Lee Min Leong1, David Wharton4, Narayan Subramanian1, Bhargav Karamched2, 3, 4, Richard Bertram2, 3, 4, Douglas A. Storace1, 2, 3. 1Dept of Biological Science, Florida State University, Tallahassee, FL, USA. 2Program in Neuroscience, Florida State University, Tallahassee, FL, USA. 3Institute of Molecular Biophysics, Tallahassee, FL, USA. 4Dept of Mathematics, Florida State University, Tallahassee, FL, USA

164

EVOLUTIONARY DIVERSITY AND FUNCTION OF ODORANT RECEPTORS IN BIRDS Robert Driver1, Mona Marie1, Hiroaki Matsunami1, Christopher Balakrishnan2. 1Duke University School of Medicine, Durham, NC, USA. 2National Science Foundation, Alexandria, VA, USA

166

ENGINEERING INSECT ODORANT RECEPTORS TOWARDS VOLATILES OF INTEREST Rhodry Brown, Hiroaki Matsunami. Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA

168

HOW LOCAL AND LATERAL INHIBITION SHAPE THE ODORANT RESPONSE FUNCTION IN THE OLFACTORY BULB David Wharton4, Lee Min Leong1, Bhargav Karamched2, 3, 4, Douglas A. Storace1, 2, 3, Richard Bertram2, 3, 4. 1Department of Biological Science, Florida State University, Tallahassee, FL, USA. 2Program in Neuroscience, Florida State University, Tallahassee, FL, USA. 3Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA. 4Department of Mathematics, Florida State University, Tallahassee, FL, USA

170

ODORANT RECEPTOR ANTAGONISM AS A MECHANISTIC BASIS FOR MALODOR COUNTERACTION Michael Cohanpour, Daniel A. Raps, Randy Arroyave, Elisabeth Peters, Gary Marr, Benedicte Le Calve, Casey Trimmer, Lily Wu, Jessica H. Brann, Patrick Pfister. dsm-firmenich, Plainsboro, NJ, USA

172

SUBTHRESHOLD MODULATION OF VARIETAL IDENTIFICATION BY 1, 1, 6-TRIMETHYL-1, 2-DIHYDRONAPHTHALENE UNDER CONTROLLED OLFACTORY DELIVERY Hansheng Chen, Quinlin Wu, Terry Acree. Cornell University, Ithaca, NY, USA

174

THE AOB MITRAL CELLS PROVIDE A CELLULAR BASIS FOR THE INDEPENDENT ENCODING OF CONSPECIFIC SEX Xubo Leng, Timothy E. Holy. Washington University in St. Louis, St. Louis, MO, USA

176

DEVELOPMENT- AND MICROBIOME-DRIVEN BILE ACID SIGNATURES AS SOCIAL CHEMOSIGNALS IN THE MOUSE VOMERONASAL SYSTEM VarunHaran Manoharan, Julian P Meeks. University of Rochester Medical School, Rochester, NY, USA

178

A COMPUTATIONAL FRAMEWORK FOR MULTISENSORY GROUNDING OF OLFACTORY REPRESENTATIONS Kordel France1, Tian Yu2, Michelle Niedziela3. 1Scentience, Dallas, TX, USA. 2Amai, Denver, CO, USA. 3Nerdoscientist, Chalfont, PA, USA

10:15 - 12:15 PM SYMPOSIUM

INDUSTRY SYMPOSIUM: DATA DRIVEN TOOLS FOR SENSORY PREDICTION Chair/Organizer: Kathryn Deibler, Xiaorong (Phoebe) Su, Ann-Marie Torregrossa, Casey Trimmer, Theresa White Bird Key Ballroom

10:15

INTRODUCTION.

10:25

EMPIRICAL EVALUATION OF HUMAN ODOR QUALITY DATASETS SUPPORTS THE USE OF LEXICAL METHODS FOR COLLECTING BIG DATA Emily J. Mayhew1, Joel D. Mainland2. 1Michigan State University, East Lansing, MI, USA. 2Monell Chemical Senses Center, Philadelphia, PA, USA

10:55

PREDICTING ODOR MIXTURE CHARACTER FROM CHEMICAL STRUCTURE Xuebo Song1, Yuanfang Guan2, Matej Hladis3, 4, Nachman Keren5, 6, Maxence Lalis3, Leonor Saiz7, Jose Vilar8, 9, Evan Guerra1, 10, Yikun Han10, Ashok Palaniappan11, Maria Diaz12, Gaia Andreoletti12, Verena Chung12, Robert Pellegrino1, Pablo Meyer13, Joel D. Mainland1, 14. 1Monell Chemical Senses Center, Philadelphia, PA, USA. 2Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. 3Institut de Chimie de Nice, Universite Cote drAzur, Nice, France. 4Department of Computer Science, University of Oxford, Oxford, United Kingdom. 5Department of Statistics a Data Science, The Hebrew University of Jerusalem, Jerusalem, Israel. 6Food Science and Nutrition, The Hebrew University of Jerusalem, Jerusalem, Israel. 7Department of Biomedical Engineering, University of California Davis, Davis, CA, USA. 8Biofisika Institute (CSIC, UPV/EHU), University of the Basque Country, Bilbao, Spain. 9IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. 10School of Information Sciences, University of Illinois Urbana-Champaign, Champaign, IL, USA. 11School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, India. 12Sage Bionetworks, Seattle, WA, USA. 13IBM Research, New York, NY, USA. 14Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

11:15

SCALING SENSORY ANNOTATION OF ODOR MIXTURES WITH A PRIOR-GUIDED SENSORY ANNOTATION TOOL Marissa L. Kamarck1, Wesley Qian1, Richard Gerkin1, 2. 1Osmo Labs, PBC, New York, NY, USA. 2School of Life Sciences and School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ, USA

11:45

PREDICTING SENSORY OUTCOMES: INTEGRATING RECEPTOR NEUROBIOLOGY WITH AI TOOLS Jessica H. Brann, Daniel A. Raps, Georgia M. Pierce, Giulia Papiani, Lily Wu, Randy Arroyave, Casey Trimmer, Patrick Pfister. dsm-firmenich, New York, NY, USA

THE APPETITION AXIS: INTEGRATING PHASIC SENSORY AND PHYSIOLOGICAL SIGNALS TO DRIVE INGESTION Chair/Organizer: Lindsey Schier Sawyer Key Ballroom

10:15

INTRODUCTION TO THE APPETITION AXIS: INTEGRATING SENSORY CUES TO DRIVE INGESTION Lindsey A. Schier. Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA

10:25

PHASIC GUT FEEDBACK SHAPES FLAVOR-NUTRIENT LEARNING Kevin P. Myers. Bucknell University, Lewisburg, PA, USA

10:55

NUTRITIONAL REPROGRAMMING OF ORAL GLUCOSENSING Sandrine Chometton1, Lindsey A. Schier2. 1Universite Bourgogne Europe, Institut Agro, CNRS, INRAE, UMR CSGA, Dijon, France. 2Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA

11:15

FLUID BALANCE REVISITED: ORAL, POSTORAL, AND CENTRAL SIGNALS DRIVING WATER INTAKE Derek Daniels. Department of Biological Sciences and the Center for Ingestive Behavior Research, University at Buffalo, SUNY, Buffalo, NY, USA

11:45

MCH AND THE DRIVE TO CONTINUE: HYPOTHALAMIC CONTROL OF NUTRIENT-BASED APPETITION Scott E Kanoski. Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA

12:15 - 2:00 PM LUNCH ON OWN

LUNCH ON OWN Lunch On Own

12:30 - 1:30 PM EVENT

OUTREACH EVENT:PRESIDENT BARACK OBAMA LIBRARY Offsite

2:00 - 3:30 PM WORKSHOP

PRACTICAL DEMONSTRATIONS OF CLINICAL CHEMOSENSORY TESTS Chair/Organizer: Thomas Hummel Jacaranda Hall This practical session is meant to provide a very practical overview about techniques that are used in a clinical context to assess chemosensory functions, including olfactory, gustatory, and trigeminal functions. In addition, techniques to address psychological/cognitive issues related to olfactory function and dysfunction will be shown. The various techniques will be presented by researchers experienced in clinical chemosensory research, including Bob Pellegrino from Philadelphia, Caroline Huart from Brussels, and Akshita Joshi from Bethesda and Thomas Hummel from Dresden. There will be 4 stations, and the participants would rotate clockwise through stations 1 to 4. They will stay at each station for 15 min. The 4 stations will be: Station 1: Smell testing (e. g, Sniffin Sticks, UPSIT, CCCRC test, SSParoT, retronasal testing): Thomas Hummel, Dresden, Germany; Station 2: Taste testing (e. g, taste sprays, taste strips, electrogustometry, PROP/PTC test): Robert Pellegrino, Philadelphia, PA, USA; Station 3: Trigeminal testing (e. g, lateralization, AMMOLA-test, oral capsaicin test, CO2 threshold): Akshita Joshi, Bethesda, USA; Station 4: Psychological testing/questionnaires (e. g, SNOT, QOD, WHO wellbeing, MOCA): Caroline Huart, Brussels, Belgium

THE BARRY DAVIS NIH FUNDING WORKSHOP Bird Key Ballroom

2:00

NIH UPDATES FOR EARLY AND ESTABLISHED INVESTIGATORS.

2:30

NIDCD WORKSHOP FOR TRAINEES AND NEW INVESTIGATORS.

3:30 - 5:30 PM POSTER SESSION

POSTER SESSION II (click to view) (click to close) Pavilion

AWARD FINALIST

101

DON TUCKER FINALIST: OLFACTORY CODING ACROSS VENTRAL SUBREGIONS OF THE HIPPOCAMPUS Anna C. Kolstad1, 2, Karol P. Szymula1, 2, Krishnan Padmanabhan1, 3, 4. 1Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA. 2Medical Scientist Training Program, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. 3Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. 4Center for Visual Science, University of Rochester, Rochester, NY, USA

103

ACHEMS UNDERGRAD FINALIST: INHIBITION OF FOCAL ADHESION KINASE LIMITS AXON GROWTH FROM OLFACTORY SENSORY NEURONS FOLLOWING INJURY Morning Dove TJ Rose, Derek Cox, Diego Rodriguez-Gil, Cuihong Jia. Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA

105

DON TUCKER FINALIST: DISTINGUISHING THE OLFACTORY EPITHELIUM USING AN FDA-APPROVED DYE & MACHINE LEARNING METHODS Skylar A Suarez1, Emily A Gibson1, Diego Restrepo2, 3. 1Department of Bioengineering, University of Colorado Anschutz Medical Campus, Denver, CO, USA. 2Department of Physiology a Biophysics, Stony Brook University, Stony Brook, NY, USA. 3Department of Cell a Developmental Biology, University of Colorado Anschutz Medical Campus, Denver, CO, USA

107

ACHEMS UNDERGRAD FINALIST: SPATIAL GENE EXPRESSION PROFILING REVEALS ACUTE AND PERSISTENT OLFACTORY BULB NEUROIMMUNE RESPONSES TO SARS-COV-2 INFECTION Yaejin Kim1, Jiaying Liu1, Anthony Weidner1, Garret Roth1, Lark Coffey2, Hongwei Liu2, Qizhi Gong1. 1Department of Cell Biology and Human Anatomy, UC Davis School of Medicine, Davis, CA, USA. 2Department of Pathology, Microbiology a Immunology, UC Davis School of Veterinary Medicine, Davis, CA, USA

109

ACHEMS UNDERGRAD FINALIST: IDENTIFICATION OF AN OLFACTORY RECEPTOR INVOLVED IN NEWBORN RABBITS’ RESPONSIVENESS TO THE MAMMARY PHEROMONE: MOLECULAR GENETIC EVIDENCE Victoria Ko1, Gerard Coureaud2, Patricia Duchamp-Viret2, Hiroaki Matsunami1. 1Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, Durham, NC, USA. 2Lyon Neuroscience Research Center - ENES team, CNRS/Inserm/Lyon 1 and Jean Monnet Universities, Lyon, France

111

ACHEMS UNDERGRAD FINALIST: TESTING A RELATIONSHIP BETWEEN ODOR MIXTURE PERCEPTION AND WORKING MEMORY CAPACITY Elijah Wakefield1, Chong Zhao2, 3, Leslie M. Kay1, 2, 3. 1The College, Chicago, IL, USA. 2Department of Psychology, Chicago, IL, USA. 3Institute for Mind and Biology, The University of Chicago, Chicago, IL, USA

113

ACHEMS UNDERGRAD FINALIST: OPTIMIZING SURGICAL ACCESS TO THE NODOSE PETROSAL GANGLIA  Hanna R. Rodriguez, Hojoon Lee. Northwestern University, Evanston, IL, USA

115

DON TUCKER FINALIST: THE ROLE OF STIMULUS TEMPERATURE ON SALT TASTE PERCEPTION IN MICE. Mariela E. Marques, Roberto Vincis. Department of Biological Sciences and Program in Neuroscience, Florida State University, Tallahassee, FL, USA

117

DON TUCKER FINALIST: INVESTIGATING ESTABLISHMENT OF SOX9+ TASTE PROGENITORS IN THE CIRCUMVALLATE PAPILLA Amanda Stenzel1, 2, 3, Trevor Isner1, 2, 3, Tricia Lee4, Linda Barlow1, 2, 3. 1Department of Cell a Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 2Cell Biology, Stem Cells and Development Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 3Rocky Mountain Taste a Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 4Developing Scholars Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

119

ACHEMS UNDERGRAD FINALIST: PALATABILITY-DEPENDENT ACTIVATION OF OREXIN NEURONS IN THE LATERAL HYPOTHALAMUS Kat Browning, Kathleen C. Maigler, Donald B. Katz. Brandeis University, Waltham, MA, USA

121

ACHEMS UNDERGRAD FINALIST: SEX-DEPENDENT ESTROGENIC REGULATION OF PERIPHERAL FAT TASTE SIGNALING Kaylee Perez1, 2, Emeline Masterson1, 2, Eloisa Grajales1, Caroline Ferrarin1, Timothy A. Gilbertson2. 1Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA. 2Medicine, University of Central Florida, Orlando, FL, USA

123

DON TUCKER FINALIST: MIRACULIN (MIRACLE BERRY) AS A POTENTIAL MITIGATION TO IMPROVE TASTE PERCEPTION IN HEAD & NECK CANCER PATIENTS Nidhi Jha1, Lauren Gastineau1, Joanne Xu1, Apoorva Ramaswamy1, Lauren Miller1, Christopher Simmons2, Kai Zhao1. 1The Ohio State University Department of Otolaryngology, Columbus, OH, USA. 2The Ohio State University Department of Food Sciences and Technology, Columbus, OH, USA

125

DON TUCKER FINALIST: SWEETNESS PREFERENCE AND EATING BEHAVIORS IN HABITUAL AND NON-HABITUAL CONSUMERS OF LOW-CALORIE SWEETENED PRODUCTS. Stephanie Okoye1, Yanina Pepino1, 2, 3. 1Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA. 2Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, IL, USA. 3Carle Illinois College of Medicine, Urbana, IL, USA

127

DON TUCKER FINALIST: TEX15 CONTROLS RUNAWAY OLFACTORY RECEPTOR TRANSCRIPTION TO NECESSITATE DIVERSE OLFACTORY RECEPTOR CHOICE Nusrath Yusuf1, Jerome Kahiapo1, David Brann3, Alina Irvine2, Josh Danoff1, Silas Sun1, Nader Boutros-Ghali1, Paige Kramer1, Sandeep Datta3, Jackie Yang1, Kevin Monahan1. 1Rutgers University, Highland Park, NJ, USA. 2Swarthmore College, Swarthmore, PA, USA. 3Havard Medical School, Boston, MA, USA

OLFACTORY RECEPTOR N

129

IDENTIFICATION OF AN OLFACTORY RECEPTOR INVOLVED IN NEWBORN RABBITS' RESPONSIVENESS TO THE MAMMARY PHEROMONE: BEHAVIORAL EVIDENCE Gerard Coureaud1, Hiroaki Matsunami2, Victoria Ko2, Patricia Duchamp-Viret1. 1Lyon Neuroscience Research Center - ENES team, CNRS/Inserm/Lyon 1 and Jean Monnet Universities, Lyon, France. 2Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA

131

GENOME-WIDE ASSOCIATION STUDY META-ANALYSIS OF DIETARY INTAKE IN TWO COHORTS IDENTIFIES SEVEN NOVEL OLFACTORY RECEPTOR ASSOCIATIONS Joanne Cole1, Maizy Brasher1, Franco Giulianini2, Daniel Chasman2. 1Department of Biomedical informatics, University of Colorado School of Medicine, Aurora, CO, USA. 2Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA

133

IMMATURE OLFACTORY SENSORY NEURONS PROVIDE COMPLEMENTARY INPUT IN THE HEALTHY OLFACTORY SYSTEM Jordan D. Gregory1, 2, Ryan S. Herzog1, 2, Kendall A. Curtis1, Michael I. Marar1, Claire E. J. Cheetham1. 1Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA. 2Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA, USA

135

EVOLUTIONARILY CONSERVED MECHANISMS OF SHORT-CHAIN ALDEHYDE RECOGNITION BY THE OLFACTORY RECEPTOR OR6B1 Haruto Kudo, Reina Kanemaki, Masafumi Yohda, Yosuke Fukutani. Tokyo University of Agriculture and Technology, Koganei, Japan

137

TEX15 AS A MARKER OF TRANSIENT MULTI-ORS EXPRESSION IN DEVELOPING OLFACTORY NEURONS Kaitao Zhao, Nusrath Yusuf, Joshua Danoff, Kevin Monahan. Rutgers University, PISCATAWAY, NJ, USA

139

WHAT DO WE REALLY SMELL: REAL-TIME CHEMICAL SAMPLING AT THE OLFACTORY EPITHELIUM Irene Zanettin1, Frans Norden1, Mikael Lundqvist1, Artin Arshamian1, Johan N. Lundstrom1, 2, 3. 1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. 2Monell Chemical Senses Center, Philadelphia, PA, USA. 3Department of Otorhinolaryngology, Karolinska University Hospital, Stockholm, Sweden

141

MULTISTEP LIGAND ASSOCIATION REVEALS HOW DYNAMIC EXTRACELLULAR GATING CONTROLS ODORANT AGONISM AND ANTAGONISM IN OLFACTORY RECEPTORS Mona A. Marie1, Ning Ma2, Da Takase4, Hiroaki Matsunami1, 3. 1Molecular Genetics and Microbiology Department, Duke Unversity School of Medicine, Durham, NC, USA. 2Department of Computational a Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, NC, USA. 3Department of Neurobiology, Duke University, Durham, NC, USA. 4Sensory Science Research, Kao Corporation, Tochigi, Japan

DEVELOPMENT/REGENERA

143

ODOR STIMULATION IN THE MOUSE OLFACTORY EPITHELIUM PROMOTES TRANSIT AMPLIFICATION WITHIN A SUBSET OF NEURONAL LINEAGES Alyssa Granley, Madeline Smith, Kawsar Hossain, Stephen Santoro. Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

145

ZONA PELLUCIDA LIKE DOMAIN CONTAINING 2 MEDIATES STIMULATION-DEPENDENT NEUROGENESIS OF SPECIFIC OLFACTORY SENSORY NEURON SUBTYPES IN MICE Karlin Rufenacht, Alexa Asson, Alyssa Granley, Kawsar Hossain, Amanda Stenzel, Madeline Smith, Stephen Santoro. Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

147

ASYMMETRIC HISTONE INHERITANCE REGULATES OLFACTORY STEM CELL FATES DURING REGENERATION Binbin Ma1, 2, Guanghui Yang1, 2, Jonathan Yao2, Charles Wu2, Jean P Vega2, Gabriel Manske3, Saher S Hammoud3, Satrajit Sinha4, Abhyudai Singh5, Haiqing Zhao2, Xin Chen1, 2. 1Howard Hughes Medical Institute, Baltimore, MD, USA. 2Johns Hopkins University, Baltimore, MD, USA. 3University of Michigan, Ann Arbor, MI, USA. 4SUNY at Buffalo, Buffalo, NY, USA. 5University of Delaware, Newark, DE, USA

149

NEUROGENESIS IN THE OLFACTORY EPITHELIUM OF ADULT ZEBRAFISH FOLLOWING OLFACTORY BULB LESIONS Rebecca Post, Nereyda Sanchez-Gama, Lexus Putt, Erika Calvo-Ochoa. Hope College, Holland, MI, USA

151

SUBPOPULATIONS OF GUSTATORY NEURONS DIFFER IN THEIR SENSITIVITY TO BDNF Mara J. Stout, Alvine J. Smith, Robin F. Krimm. University of Louisville, Louisville, KY, USA

153

IMMUNE RESPONSE DYNAMICS IN THE ANTERIOR TASTE FIELD AFTER NERVE INJURY Joshua I. Brown1, 2, Yonggang Bao2, Tagwa Ali2, Emma Heisey1, 2, Osarume Ogalala2, Taylor Hardeman2, Lynnette McCluskey2. 1Graduate Program in Neuroscience, Augusta, GA, USA. 2Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA

155

TNF/TNFR1 SIGNALING MEDIATES INFLAMMATION-INDUCED REMODELING OF GUSTATORY INNERVATION Emily Holder, Ryan Wood, Lindsey Macpherson. University of Texas at San Antonio, San Antonio, TX, USA

CHEMESTHESIS

157

TRPM8-MEDIATED COOL-INDUCED ANALGESIA IN A MOUSE MODEL OF CHEMESTHETIC ORO-TRIGEMINAL PAIN Chris Brooks, Christian Lemon. University of Oklahoma, Norman, OK, USA

159

MICE THAT LACK TRIGEMINAL THERMOSENSORY AFFERENTS RETAIN SENSITIVITY TO ORAL TEMPERATURES Catori J. Roberts, Rosalie C. Maltby, Christian H. Lemon. University of Oklahoma, Norman, OK, USA

161

DETERMINING HOW THE INTRANASAL CHEMESTHETIC SENSATION OF COCAINE CONTRIBUTES TO ADDICTION Maria F. Ramirez1, Abhishek Gour2, Sarah E. Sniffen1, Emma Watson1, Abhisheak Sharma2, Daniel W. Wesson1. 1Department of Pharmacology a Therapeutics and Department of Neuroscience, Florida Chemical Senses Institute, University of Florida College of Medicine, Gainesville, FL, USA. 2Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL, USA

163

CHEMOSENSORY ERPS SUGGEST PERIPHERALLY DRIVEN OLFACTORY-TRIGEMINAL INTERACTIONS IN OLDER ADULTS Sarah Brosse1, Olivier Fortier-Lebel2, Emilie Hudon2, Keven Lapointe1, Johannes Frasnelli1, 3, 4. 1Department of Anatomie, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC, Canada. 2Department of Psychology, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC, Canada. 3Research Center, Sacre Coeur Hospital, Montreal, QC, Canada. 4Research Center, Institut universitaire de geriatrie de Montreal, Montreal, QC, Canada

165

INDIVIDUAL VARIABILITY IN METALLIC SENSATION IS ASSOCIATED WITH TRANSIENT RECEPTOR POTENTIAL VANILLOID 1 (TRPV1) POLYMORPHISMS. Sasi Tansaraviput, Alissa A. Nolden. University of Massachusetts Amherst, Amherst, MA, USA

167

UNEARTHING CHEMESTHESIS AND CHEMESENSORY GENES IN THE EARTHWORM DENDROBAENA VENETA WITH LONG-READ TRANSCRIPTOMICS. Jonathan G Mebrahtu1, Adriana Messyasz2, Alexander Lemenze2, 3, Cecil J Saunders1. 1Department of Biological Sciences, School of Integrative Science and Technology, Kean University, Union, NJ, USA. 2Molecular and Genomics Informatics Core, Rutgers New Jersey Medical School, Newark, NJ, USA. 3Department of Pathology, Immunology, and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA

169

STRUCTURAL EXPLORATION OF MUSK RECOGNITION AND ACTIVATION MECHANISMS OF ODORANT RECEPTORS Dan Takase, Hiroaki Matsunami. Duke University, Durham, NC, USA

METABOLISM & OBESITY

171

TAS1R2-TAS1R3 RECEPTORS MODULATE PANCREATIC BETA CELL RESPONSES TO INCREASES IN GLUCOSE Paul A. S. Breslin1, 2, Liora S. Katz3, Samuel Deutsch1, Gary J. Schwartz4, Sarah A. Stanley3, Paul M. Wise2, Donald K. Scott3. 1Rutgers University, New Brunswick, NJ, USA. 2Monell Chemical Senses Center, Philadelphia, PA, USA. 3Icahn School of Medicine at Mt Sinai, New York, NY, USA. 4Albert Einstein College of Medicine, Bronx, NY, USA

173

A NEW TOOL TO IDENTIFY AND PHARMACOLOGICALLY CHARACTERIZE GLP-1 STIMULI Valentina Casa, Sara Montelatici, Laura Stucchi, Camilla Trovesi, Paola Bonetti, Stefania De Cesare, Alice Segnali, Loredana Redaelli, Viviana Agus, Alberto Di Silvio, Marcel Winnig. Axxam SpA, Milan, Italy

175

MELANIN-CONCENTRATING HORMONE AND OREXIN NEUROPEPTIDES FOUND TO COMMUNICATE FROM THE HYPOTHALAMUS TO THE OLFACTORY BULB Julia J. Won1, Meizhu Qi1, 2, 4, Catherine Rodriguez1, Douglas A. Storace1, 2, 3. 1Department of Biological Science, Florida State University, Tallahassee, FL, USA. 2Program in Neuroscience, Florida State University, Tallahassee, FL, USA. 3Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA. 4Department of Pediatric Neurology, Baylor College of Medicine, Houston, TX, USA

177

GUT-BRAIN MODULATION OF TASTE AFTER SPINAL CORD INJURY AND SLEEVE GASTRECTOMY: METABOLIC STATE AND SELECT MICROBIAL CONTRIBUTORS Jonathan Snyder, Gregory Holmes, Andras Hajnal. Department of Neuroscience and Experimental Therapeutics, Penn State University College of Medicine, Hershey, PA, USA

179

DISRUPTION OF TASTE CELL RENEWAL IN DIET-INDUCED OBESITY Sabrina K Choi, Robin Dando. Cornell University, Ithaca, NY, USA

5:45 - 6:45 PM EVENT

NETWORKING RECEPTION Garden Courtyard The Networking Reception is an opportunity for the AChemS community to get together in an informal setting. We will honor the recipients of the Travel Fellowship and then enjoy conversations with junior and senior colleagues. Attendees who signed up for the Mentoring Matrix Program in advance will meet with their Matrix members. There will also be the possibility of joining or creating new Mentoring Matrices on site.

7:30 - 9:30 PM LECTURE

POLAK AWARDS LECTURES Chair/Organizer: Bradley Goldstein Sawyer Key Ballroom The Polak Foundation Awards are awarded in honor of the Elsje-Werner-Polak Memorial Fund in memory of our niece gassed by the Nazis in 1944 at age 7: Ghislaine Polak and the late Ernest Polak.

7:30

EVOLUTIONARY DIVERSITY AND FUNCTION OF ODORANT RECEPTORS IN BIRDS Robert Driver1, Mona Marie1, Hiroaki Matsunami1, Christopher Balakrishnan2. 1Duke University School of Medicine, Durham, NC, USA. 2National Science Foundation, Alexandria, VA, USA

7:50

A SENSORY CIRCUIT FOR SOCIAL LEARNING Kara A. Fulton1, Slater Sharp1, Gloria DuMaine1, Sidharth Annapragada1, Phelipe E. Silva1, 2, Sebastian Kruettner1, 3, Emma Robinson1, 4, Sandeep R. Datta1. 1Harvard Medical School, Boston, MA, USA. 2University of Sao Paulo, Sao Paulo, Brazil. 3Broad Institute, Cambridge, MA, USA. 4Scripps Research Institute, La Jolla, CA, USA

8:10

VECTOR-BASED TASTE REPRESENTATIONS OF FOOD ODOURS PREDICT APPETITIVE VALUE Putu A Khorisantono1, Apostolia Filippopoliti1, Maria G Veldhuizen2, 3, Janina Seubert1. 1Karolinska Institutet, Solna, Sweden. 2Mersin University, Mersin, Turkey. 3Bilkent University, Ankara, Turkey

8:30

ASYMMETRIC HISTONE INHERITANCE REGULATES OLFACTORY STEM CELL FATES DURING REGENERATION Binbin Ma1, 2, Guanghui Yang1, 2, Jonathan Yao2, Charles Wu2, Jean P Vega2, Gabriel Manske3, Saher S Hammoud3, Satrajit Sinha4, Abhyudai Singh5, Haiqing Zhao2, Xin Chen1, 2. 1Howard Hughes Medical Institute, Baltimore, MD, USA. 2Johns Hopkins University, Baltimore, MD, USA. 3University of Michigan, Ann Arbor, MI, USA. 4SUNY at Buffalo, Buffalo, NY, USA. 5University of Delaware, Newark, DE, USA

8:50

A QUANTITATIVE PERCEPTUAL FRAMEWORK FOR RECONSTRUCTING COMPLEX FOOD ODORS Xuebo Song1, Christiane Danilo1, Robert Pellegrino1, Joel Mainland1, 2. 11Monell Chemical Senses Center, Philadelphia, PA, USA. 22Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA

9:10

CONNECTOMIC MAPPING OF PHARYNGEAL AND GUT SENSORY CIRCUITS IN ADULT DROSOPHILA Dimitrios S. Giakoumas1, Julia M. Zhu1, Alaina Jamal2, Zepeng Yao1. 1University of Florida, Gainesville, FL, USA. 2Pine Crest School, Fort Lauderdale, FL, USA