Presentation Details
| New approach methodologies (NAMs) in chemosensory and interoception research Benjamin Smith, Danielle Reed. Monell Chemical Senses Center, Philadelphia, PA, USA |
Abstract
Chemosensory and interoceptive systems represent a primary interface between the external chemical environment and internal physiology, positioning them at the center of “exposome” science. This symposium examines the role of New Approach Methodologies, emphasizing their integration into established experimental traditions rather than their use in isolation. From a regulatory and exposure science perspective informed by work across academia, industry, and government, the session highlights how human-relevant NAM platforms, including organoids, ex vivo transitional systems, and computational models, can strengthen links between exposure, dose, and biological response. Speakers will underscore the continued importance of experimental systems that preserve intact neural circuits, sensory-driven behavior, and learning, which have been central to foundational discoveries in chemosensory neuroscience, including work that has defined how the brain reads olfactory, gustatory, and interoceptive signals. By drawing on complementary examples across model systems, the symposium emphasizes convergence and cross-validation as essential scientific principles. Discussions will focus on how insights from animal studies inform the design and interpretation of NAMs, and how NAMs in turn can refine hypotheses. Framed within an exposome context, this session aims to foster inclusive and rigorous dialogue across the AChemS community on how best to integrate emerging and established approaches to advance chemosensory science.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.