Presentation Details
| MCH and the Drive to Continue: Hypothalamic Control of Nutrient-Based Appetition Scott E Kanoski. Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA |
Abstract
Peripheral nutrient detection is rapidly communicated to the brain and translated into decisions about meal size and food choice. While the neural mechanisms that limit intake and terminate meals are well characterized, the central processes that amplify ingestion in response to nutrient signals – i.e., “appetition” – remain poorly understood. The hypothalamus, as a central hub for the integration of nutrient sensing and motivated behavior, represents a likely target for the central mediation of appetition. This presentation will review data establishing a role for the hypothalamic neuropeptide melanin-concentrating hormone (MCH) as a key central mediator driving nutrient-based appetition. Based on emerging findings, a framework will be presented whereby different populations of MCH neurons located in the lateral hypothalamus and the zona incerta promote distinct components of appetition.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.