Presentation Details
| High-resolution MRI of laminar structures in the human olfactory bulb in vivo Jun Hua1, 2. 1F.M.Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA |
Abstract
The olfactory bulb (OB) consists of six distinct layers. The axonal projections from the OSNs converge in the olfactory glomeruli contained in OB layer II, the glomerular layer (GL), from which it synapses onto neurons and interneurons in subsequent layers. High resolution MRI of ex vivo human OB specimen has been attempted previously at 3T. However, the image quality was not clinically readable, and the duration of MRI scan (100 minutes) was prohibitory for clinical exams. Here, we show that optimized MRI scans performed on high-field (7T) human MRI systmes can image structural laminar organization of the human OB in vivo. With a spatial resolution of 0.4 mm and scan time of 12 minutes, laminar structures in the OB can be visualized in healthy human subjects. Laminar structures with signal intensities corresponding to OB Layers I, II, III and VI in ex vivo images can be clearly identified in our in vivo images. The width of in vivo OB was wider than ex vivo OB specimen (~3.4mm vs. ~2.1mm). Importantly, the OB Layer II (glomerular, GL) can be segmented in the in vivo images with an approximate width of 0.6 mm.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.
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