Presentation Details
| How Local and Lateral Inhibition Shape the Odorant Response Function in the Olfactory Bulb David Wharton4, Lee Min Leong1, Bhargav Karamched2, 3, 4, Douglas A.Storace1, 2, 3, Richard Bertram2, 3, 4. 1Department of Biological Science, Florida State University, Tallahassee, FL, USA.2Program in Neuroscience, Florida State University, Tallahassee, FL, USA.3Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, USA.4Department of Mathematics, Florida State University, Tallahassee, FL, USA |
Abstract
Coding of olfactory signals at the level of the olfactory bulb involves both intraglomerular and interglomerular inhibition. We use mathematical modeling to understand how each of these processes may contribute to mitral/tufted cell (MTC) output signals. In particular, we seek to understand how the two forms of inhibition contribute to non-monotonic responses of MTCs over a range of odorant concentrations (see poster by Leong et al.). We perform an analysis of a simple mathematical model to demonstrate how differences in the olfactory receptor neuron (ORN) odorant response functions over a range of concentrations map into different types of MTC response functions. We also highlight how the two forms of inhibition affect this mapping and achieve this via precisely characterizing the ORN parameter space using bifurcation theory. We show that parameters affecting intraglomerular inhibition are mathematically separable from those affecting the ORN response and interglomerular inhibition; thus, they have independent effects on the MTC response. This is true regardless of the structure of the interglomerular inhibitory network, which is currently unknown.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.
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