Presentation Details
| The role of anterior piriform cortex in social recognition in mice Ryan C.Scauzillo, Roshni Rameshkumar, Max L.Fletcher. University of Tennessee Health Science Center, Memphis, TN, USA |
Abstract
Engagement in proper social behaviors requires individuals be able to detect signals provided by other conspecifics, differentiate the information, and then act accordingly. For rodents, detection of social signals occurs through both the main and accessory olfactory systems and both circuits show importance for engaging in proper social behaviors. Within the main olfactory system, the anterior piriform cortex is the main odor processing region and demonstrates responses to social signals. We hypothesize that the anterior piriform cortex is an integral component for ability to engage in social recognition. We utilized head-mounted miniscopes to record neural activity of freely moving mice during a three-phase social recognition paradigm. Within a three-chambered social arena, mice were given the ability to interact with a same-sex conspecific and an empty cylinder for 5 minutes followed by a 10-minute intertrial phase. Then the mice were allowed to interact with a novel and the familiar same-sex conspecific for 5 minutes. Mice demonstrated social recognition through more time spent with and stronger neural responses to novel compared to familiar conspecifics. Additionally, a principal component analysis of neural activity during investigations showed separation based on familiarity. Our data appears to indicate two things: A) anterior piriform cortex plays a role in social recognition and B) familiarity may drive neural population responses and coding. The information encoded within anterior piriform cortex is likely then relayed to other social behavior relevant brain regions. Currently we are working to elucidate the mechanisms that enable social recognition within anterior piriform cortex, what information is then relayed, and how the information is relayed to other social behavior regions.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.
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