Presentation Details
| Mobility, physical activity, and social activity impairments, particularly in male ApoE ε4 carriers, are associated with olfactory and cognitive dysfunction Claire Murphy1, 2, Taline Bicakci1. 1San Diego State University, San Diego, CA, USA.2University of California, San Diego, La Jolla, CA, USA |
Abstract
Important studies have revealed that olfactory dysfunction is associated with poorer quality of life (QoL). Those studies were primarily associated with ingestion. Here we focused on issues related to cognitive decline. The devastating impact of Alzheimer’s Disease (AD) necessitates developing intervention strategies targeting modifiable risk factors. QoL impairments may be associated with cognitive and olfactory dysfunction in preclinical AD and represent potential modifiable risk factors. We analyzed data from the 548 adults 60+ yrs from the Rancho Bernardo Study who had both National Geographic Smell Survey assessments and genetic testing for ApoE ε4 status, a genetic predictor of AD risk. They were assessed with the Mini Mental Status Examination and Quality of Well-Being Scale. QoL domains included overall functioning and specific impairments in physical activity, social activity, and mobility. In this baseline analysis multivariate linear regressions examined associations between QoL impairments, cognitive and olfactory function, controlling for age, sex, education, and antidepressant/anxiolytic use. Lower overall functioning, physical and social activity impairments were associated with olfactory dysfunction. In females, social activity and mobility impairments related to olfactory dysfunction. Male ε4 carriers with greater social and mobility impairments had worse olfactory function. Findings that mobility, physical activity and social activity impairments, especially in male ε4 carriers, are associated with olfactory and cognitive dysfunction suggest the need to investigate the direction of the effects and the potential for interventions. Further research is warranted to investigate underlying mechanisms and predictive value for future decline. NIH support: R01AG004085; R01AG062006 (CM)
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