Presentation Details
Introduction to the Appetition Axis: Integrating Sensory Cues to Drive Ingestion

Lindsey A.Schier.

Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA

Abstract


Meal size is largely determined by sensory information arising from the oral cavity and proximal gut during active ingestion. While oral and post-oral signals have mainly been studied in the context of their opposing effects on meal size, with flavor driving intake of nutritious substances and gut feedback terminating intake, Tony Sclafani and others have importantly demonstrated that nutrients can rapidly stimulate intake from post-oral sites of action, increasing meal size in the short term, and reinforcing appetitive and consummatory responses to associated oral cues over the long term through learning, phenomena collectively termed appetition (as opposed to satiation). This symposium will expand the original concept of appetition by exploring: the sequence of post-oral signals that arise during digestion and their differential effects on food learning (Myers), how metabolic cues shape taste perception and reward (Chometton), how non-caloric, essential nutrients such as water, engage appetition-like mechanisms (Daniels), and provide new evidence for the role of hypothalamic melanin-concentrating hormone in the mediation of nutrient-driven appetition (Kanoski). Together, these talks position appetition as a distributed and plastic process and suggest new directions for dissecting how chemosensory, physiological, and central signals converge to control ingestion.

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