Presentation Details
| Dynamics of neural oscillations in the olfactory bulb related to task demands Andrew Sheriff1, Gregory Lane1, Qiaohan Yang1, Adam Dede1, Naelly Arriaga1, Bruce K.Tan2, Leslie M.Kay3, 4, Christina Zelano1. 1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.2Department of Otolaryngology - Head & Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.3Department of Psychology, The University of Chicago, Chicago, IL, USA.4Institute for Mind and Biology, The University of Chicago, Chicago, IL, USA |
Abstract
Olfactory system dynamics change depending on behavioral state and can be measured via neural oscillations, for example olfactory bulb (OB) gamma power is generally enhanced during wakefulness compared to sleep. More specifically, OB gamma is enhanced during difficult learned associations of very similar odors, and beta oscillations emerge during olfactory learning, potentially serving different mechanisms. Using single-trial-precision recordings of OB local field potentials (LFPs), we explored whether these neural oscillations appear in the human OB during an odor discrimination task. A pair of odors (ketones or alcohols) that were very similar to each other (fine discrimination), but more noticeably different across pairs (coarse discrimination), were used for this task. In each trial, participants (n=6) were presented a pair of odors (fine, coarse, or same), chosen randomly among the 3 conditions, and participants then indicated whether the pair of odors were the same or different. Preliminary data shows significant beta and gamma oscillations emerging during sniffs of odors (p<0.05, permutation test against pre-sniff baseline, FDR-corrected), in line with those seen during olfactory learning tasks in rodents. Dynamics of these neural oscillations during sniffs will be related to task performance and discrimination difficulty, and task periods between sniffs will be analyzed for top-down signals, hypothesized to emerge in low gamma (30–60 Hz) and beta (15–28 Hz) bands.
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