Presentation Details
| Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb Lee Min Leong1, David Wharton4, Narayan Subramanian1, Bhargav Karamched2, 3, 4, Richard Bertram2, 3, 4, Douglas A.Storace1, 2, 3. 1Dept of Biological Science, Florida State University, Tallahassee, FL, USA.2Program in Neuroscience, Florida State University, Tallahassee, FL, USA.3Institute of Molecular Biophysics, Tallahassee, FL, USA.4Dept of Mathematics, Florida State University, Tallahassee, FL, USA |
Abstract
Animals can recognize and discriminate between different odors and the same odor over a range of concentrations. Processing within the mouse olfactory bulb (OB) may be involved, yet the underlying neural mechanisms remain unclear. Each olfactory receptor neuron (ORN) type maps to the olfactory bulb in olfactory receptor specific channels called glomeruli where they connect with the dendrites of mitral/tufted cells (MTCs), which project their axons to the rest of the brain. Differences between input and output define the functions carried out by a brain area. Using in vivo dual-color 2-photon calcium imaging from the ORNs and MTCs innervating the same glomeruli in the mouse OB, we identified that monotonically rising concentration-relationships in ORNs were transformed into different MTC response types that included monotonic and non-monotonic concentration-response relationships. Mathematical modeling was used to demonstrate that one of the non-monotonic response types is consistent with a form of interglomerular processing. We propose that the transformation from exclusively monotonic ORNs to a combination of monotonic and non-monotonic MTCs would facilitate odor discrimination and the ability to achieve concentration-invariant odor perception.
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