Presentation Details
| Individual variability in metallic sensation is associated with Transient Receptor Potential Vanilloid 1 (TRPV1) polymorphisms. Sasi Tansaraviput, Alissa A.Nolden. University of Massachusetts Amherst, Amherst, MA, USA |
Abstract
A metallic sensation is a pervasive, aversive sensory defect in divalent salt-fortified foods, yet its physiological mechanism remains unclear. Although often described as a gustatory defect, evidence suggests the involvement of a trigeminal component mediated by TRPV1. This study investigated the association between TRPV1 single-nucleotide polymorphisms (SNPs) and the suprathreshold perception of ferrous sulfate (FeSO4) and copper sulfate (CuSO4). The participants were genotyped for four TRPV1 SNPs (rs224534, rs222747, rs4790522, and rs8065080). Sensory perception was evaluated across 3 concentrations of both stimuli (0.3, 1.0, 3.0 mM). To account for individual variability, participants were segmented into 3 data-driven clusters: High, linear, and inverse metallic responders. Mixed-model ANOVA was used with genotype, concentration, and cluster as fixed effects. Results revealed a significant effect of the rs222747 on FeSO4 metallic perception (P = 0.002), with GG carriers reporting lower intensity than GC carriers (P <0.05). An interaction between genotype and cluster was also observed for rs8065080, though post hoc tests were not significant (P > 0.05). For CuSO4, a three-way interaction of the rs224534 was observed (P = 0.04); at 0.3 mM, metallic perception was higher in AA than in GA/GG carriers (P <0.05) within the high-intensity cluster. This indicates genetic modulation is not uniform but phenotype-specific at a certain concentration. These findings support a TRPV1-mediated trigeminal component in metallic sensation, suggesting divalent metal salts may engage TRPV1 differently. The interaction between TRPV1 polymorphisms and sensory phenotypes underscores the need to account for psychophysical response patterns when elucidating genetic influences on complex oral sensations such as metallic.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.
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