Presentation Details
| Validation of SCENTinel 2.0 Against Three Established Olfactory Measures Vicente Ramirez1, Emily Ho2, Fabio Setti3, Stephanie Hunter1, Anne Zola2, Ryann Kolb1, Pamela Dalton1, Valentina Parma1, 4. 1Monell Chemical Senses Center, Philadelphia, PA, USA.2Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.3Department of Psychology, Fordham University, Bronx, NY, USA.4Department of Otorhinolaryngology – Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA |
Abstract
While validated tests like 9-item NIH Toolbox Odor Identification test (NIHTOI), and the 12-item Brief Smell Identification Test (B-SIT), and 16-item Sniffin’ Sticks Odor Identification test (SS-I) accurately measure olfactory function, their length, cost, and requirement for trained administrators limit population-wide screening. SCENTinel is a rapid, self-administered screening tool that measures odor detection, identification, intensity, and pleasantness using one odor at the time, offering a scalable alternative. We validated SCENTinel’s performance in detecting smell dysfunction in a sample of 363 individuals aged 18-83 (mean: 44±19 years old) who completed all tests in one session along with demographic and health surveys. Across 9 odor versions, SCENTinel demonstrated excellent specificity (mean ≈ 0.97-0.99) and precision (mean ≈ 0.73-0.83), but lower sensitivity (mean ≈ 0.21-0.28) in detecting smell dysfunction. Fair-to-moderate agreement with gold standards (κ ≈ 0.25–0.34) was comparable to agreement among the reference tests themselves (κ ≈ 0.28–0.42). Test-retest reliability for SCENTinel was similar to NIHTOI, supporting temporal stability. SCENTinel provides 3 times faster and 2.5 times less expensive, reliable, conservative detection of smell dysfunction, supporting its use as a rapid, low-burden screening tool for population-level olfactory surveillance.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.
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