Presentation Details
| Chemosensory neuromodulation by extracellular RNA transfer Hayeon Sung1, Sven Barvoetz2, Jason Shepherd2, Sophie Caron2, Monica Dus1. 1The University of Michigan, Ann Arbor, MI, USA.2University of Utah, Salt Lake City, UT, USA |
Abstract
While it is increasingly accepted that non-neuronal support cells actively shape sensory perception, the precise molecular languages they use to converse with neurons are still being worked out. We identify the immediate early gene Activity-regulated cytoskeleton-associated protein 1 (Arc1) as a key player in the neuromodulation of the Drosophila gustatory system. We show that sweet taste sensitivity is influences by a capsid-mediated molecular 'handshake' between thecogen support cells and sensory endings. This communication is plastic and depends on nutrient sensing. By demonstrating that support cells use viral-like capsids to transfer Arc1 and tune neuronal excitability, our findings reveal a sophisticated, cargo-specific signaling axis that is fundamental to sensory and nutritional homeostasis.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.