Presentation Details
| Individual differences in cephalic phase insulin release Alexa J.Pullicin, Juyun Lim. Oregon State University, Corvallis, OR, USA |
Abstract
Cephalic phase insulin release (CPIR) is a rapid secretion of insulin that occurs following oral sensory stimulation. Previous work in humans and rodents has shown that glucose and glucose-containing carbohydrates in particular are good elicitors of this response. Nevertheless, a high degree of variability in the magnitude of CPIR to these stimuli can be observed across individuals. Here, we report on individual differences in CPIR from two groups of healthy adults following stimulation with either 1 M glucose in solution (liquid form; N=22) or mixed with gelatin (solid form; N=20). In both cases, participants performed a 45-second modified sham feed and blood samples were collected before and after stimulation. Plasma c-peptide (a proxy for insulin secretion) and insulin were then analyzed. Both stimuli elicited CPIR in most but not all individuals; those who showed a positive change in c-peptide or insulin from baseline between 2 and 6 min were categorized as CPIR “responders.” We observed a c-peptide responder rate of 91% and 65% for the glucose in liquid and solid form, respectively, and an insulin responder rate of 82% and 57% for the liquid and solid respectively. In addition, a large degree of variability was seen within the responders, with individuals’ highest c-peptide measurements ranging from 6 to 138 pmol/L and highest insulin measurements ranging from 0.4 to 32 pmol/L over 2 to 6 min. Individual data over the CPIR period will be presented to highlight this variability and the potential implications will be discussed.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.