Workshop > Session
HISTORY JOURNAL CLUB – 2024: APPETITION
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This year’s journal club will highlight the classic work of Anthony Sclafani in uncovering key principles of a phenomenon that he coined “appetition”. In contrast to satiation, where post-ingestive signals suppress gustatory pleasantness (that third piece of cake doesn’t taste nearly as good!), appetition refers to the processes that promote ingestive behaviors. Tony’s work emphasized a paradigm-shifting concept- that there are also post-ingestive reward signals. This has a number of important implications-- not only do such signals amplify hedonic value of tastes but they can also differentially condition liking. The interaction between taste and post-ingestive reward signals has a major impact on driving eating behavior and food choice. During the journal club, we will also discuss recent work that has begun to uncover the peripheral and central mechanistic bases for these phenomena.
Introduction: Dr. Ann-Marie Torregrossa
CLASSIC PAPER
Dr. Anthony Sclafani
• Zukerman S., Ackroff, K. and Sclafani, A Rapid post-oral stimulation of intake and flavor conditioning by glucose and fat in the mouse. Am J Physiol Regul Integr Comp Physiol 301: R1635-R1647, 2011
TO THE PRESENT: Dr. Molly McDougle
• Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating Molly McDougle 1, Alan de Araujo 2, Arashdeep Singh 3, Mingxin Yang 3, Isadora Braga 4, Vincent Paille 5, Rebeca Mendez-Hernandez 6, Macarena Vergara 2, Lauren N Woodie 7, Abhishek Gour 8, Abhisheak Sharma 8, Nikhil Urs 9, Brandon Warren 10, Guillaume de Lartigue 1Cell Metab 2024 Feb 6;36(2):393-407.
Wrap-up: other relevant data & synthesis (Dr. Lindsey Schier)
Introduction: Dr. Ann-Marie Torregrossa
CLASSIC PAPER
Dr. Anthony Sclafani
• Zukerman S., Ackroff, K. and Sclafani, A Rapid post-oral stimulation of intake and flavor conditioning by glucose and fat in the mouse. Am J Physiol Regul Integr Comp Physiol 301: R1635-R1647, 2011
TO THE PRESENT: Dr. Molly McDougle
• Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating Molly McDougle 1, Alan de Araujo 2, Arashdeep Singh 3, Mingxin Yang 3, Isadora Braga 4, Vincent Paille 5, Rebeca Mendez-Hernandez 6, Macarena Vergara 2, Lauren N Woodie 7, Abhishek Gour 8, Abhisheak Sharma 8, Nikhil Urs 9, Brandon Warren 10, Guillaume de Lartigue 1Cell Metab 2024 Feb 6;36(2):393-407.
Wrap-up: other relevant data & synthesis (Dr. Lindsey Schier)