Presentation Details
| Odorant Receptor Antagonism as a Mechanistic Basis for Malodor Counteraction Michael Cohanpour, Daniel A.Raps, Randy Arroyave, Elisabeth Peters, Gary Marr, Benedicte Le Calve, Casey Trimmer, Lily Wu, Jessica H.Brann, Patrick Pfister. dsm-firmenich, Plainsboro, NJ, USA |
Abstract
Malodors, such as moldy or earthy notes on fabrics, present a persistent consumer challenge. Reduction of malodor perception is traditionally attributed to perceptual masking, yet increasing evidence suggests a mechanism by which this can occur is via antagonism of odorant receptors (ORs). Here, we evaluate this relationship by testing the hypothesis that OR inhibition can predict malodor perceived intensity in human sensory evaluations across multiple malodors. An expert perfumer evaluated binary mixtures of several malodors with panels of odorants and rated their effectiveness at counteracting malodor perception. In parallel, we quantified the inhibitory effects of these compounds on the corresponding ORs using a unified inhibition index derived from in vitro heterologous assay measurements. Our results provide direct evidence that OR inhibition contributes to malodor counteraction and demonstrate that receptor‑level metrics can predict sensory counteraction performance. This work establishes a mechanistic framework for malodor control and supports OR inhibition as a general design principle for next‑generation fragrance and flavor development.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.
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