Presentation Details
| Coupling of neural oscillations in cortical networks during odor intensity perceptual decisions Andrew Sheriff1, Gregory Lane1, Adam Dede1, Qiaohan Yang1, Justin B.Morgenthaler1, Saige Teti3, Naelly Arriaga1, Chima Oluigbo3, Mohamad Koubeissi4, Joshua M.Rosenow2, Stephan U.Schuele1, Beatrice Barrra5, Joel Mainland6, 7, Christina Zelano1. 1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.2Department of Neurosurgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.3Division of Neurosurgery, Children’s National Medical Center, Washington, DC, USA.4Department of Neurology, George Washington University, Washington, DC, USA.5Neuroscience Institute, New York University, Langone Health, New York, NY, USA.6Monell Chemical Senses Center, Philadelphia, PA, USA.7Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA |
Abstract
Intensity is a fundamental aspect of perception. How brains code for intensity of olfactory stimuli is an open question. We have been studying how neural oscillations in piriform cortex might code for perceived odor intensity. We presented odors, using consistent concentration sampling bags, to patients undergoing intracranial EEG monitoring for epilepsy, using 3 concentrations of 3 odors, in addition to clean air. Participants gave an intensity rating on each trial, while we obtained high resolution LFP recordings from electrode contacts implanted throughout the brain. Preliminary data suggest gamma oscillations (30–60 Hz) in piriform cortex are stronger and last for longer duration during sniffs of strong odors, shown by comparisons of significant increases of gamma oscillations measured during strong vs. weak intensity rated trials (permutation test against pre-sniff baseline, FDR-corrected). Furthermore, machine learning approaches suggest the gamma signal is representing perceived intensity rather than concentration. This task relies not only on perception of the intensity of odors but also holding that percept in mind in order to make an accurate rating each trial, implicating areas beyond piriform cortex. The olfactory bulb is bidirectionally connected to piriform cortex and several other limbic and cortical areas, including amygdala, orbitofrontal cortex, cingulate cortex, and insula. While we continue to investigate oscillatory coding for perceived odor intensity in piriform cortex, this poster will highlight explorations of how coherent neural oscillations emerge across olfactory cortical and limbic areas, as potential mechanisms for coordinating discrete neural networks for odor perception.
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