Conference Program

Welcome! Please find the current preliminary program for AChemS 2022 listed below. Note that any aspect of this program is subject to change.

April 20 (8:00AM - 4:45 PM): ISN Symposium
April 20-23: AChemS Annual Meeting Program

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Friday, April 25th

7:30 - 9:00 AM

CONTINENTAL BREAKFAST Estero Foyer

8:00 - 10:00 AM

POSTER SESSION III Estero Ballroom

10:00 - 11:00 AM

DIVERSITY, EQUITY, INCLUSION, AND BELONGING (DEIB) LECTURE Calusa EFGH

10:00

You are whole just as you are: More to Inclusion than widening the door Dr. Deana McDonagh1, 2, 3. 1Professor of Industrial Design (School of Art + Design) .2Director of the (dis)Ability Design Studio (Beckman Institute) .3Health Innovation Professor (Carle Illinois College of Medicine)

11:00 - 12:00 PM

MEMBERSHIP BUSINESS MEETING Calusa EFGH Get involved! Join us for reports from the society leadership on the state and future of the association. All members are welcome and encouraged to attend.

12:00 - 3:00 PM

FREE TIME Lunch On Own

3:00 - 4:00 PM

JOURNAL CLUB: HISTORY OF ASSESSING LIGAND SENSITIVITY AND SELECTIVITY OF ODORANT RECEPTORS Great Egret This year’s Journal Club will highlight the evolution of methods utilized to assess the physiological role and function of odorant receptors since their discovery in 1991 by Buck and Axel. We will start by reviewing Zhao et al.’s 1998 paper, “Functional expression of a mammalian odorant receptor, ” in which the authors accomplished rat I7 receptor expression in its native environment, the olfactory sensory neuron, via recombinant adenovirus. The authors found this receptor is selective for C7 to C10 saturated aliphatic aldehydes although they did not resolve how those odorants physically interact with receptor binding sites. However, this and other expression approaches launched decades of additional work to identify ligands for the family of odorant receptors. While much progress has been made, a recent review by Lalis et al observed that a ligand has not been identified for approximately half of the known receptor variants. Thus, our discussion will include the 2024 paper by de March et al. “Engineered odorant receptors illuminate the basis of odour discrimination, ” and its application of cryo-EM to the long unresolved problem of describing odorant receptors protein structure. This exciting advancement furthers our understanding of the molecular determinants of ligand selectivity and will enable further deorphanization via in silico methodologies. AGENDA Introduction (Jessica H. Brann, Ph.D., dsm-firmenich, New York, NY, USA) Classic publication: Functional expression of a mammalian odorant receptor - PubMed (Ricardo Araneda, Ph.D., University of Maryland, College Park, MD, USA) Recent publication: Engineered odorant receptors illuminate the basis of odour discrimination - PubMed (Mona Marie, Ph.D., Molecular Genetics and Microbiology Department, Duke University School of Medicine, Durham, NC, USA)

4:00 - 6:00 PM

POSTER SESSION IV Estero Ballroom

7:00 - 9:00 PM

AWARD LECTURES Chair/Organizer: Yanina Pepino Calusa EFGH