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Unraveling Mechanisms Regulating Odor Receptor Expression in Health and Repression in Disease

Marianna Zazhytska, PhD and Sandeep Robert Datta, MD, PhD

February 19, 2025 | 11:00 AM ET

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A working sense of smell requires the appropriate pattern of expression of odor receptor genes in the nose. However, we know little about how individual OR genes are chosen for expression in the healthy olfactory epithelium, and even less about how this process might be perturbed in diseases that disrupt smell. Here we use molecular genetic approaches to identify deterministic mechanisms that govern OR expression physiologically, and to reveal viral mechanisms the dysregulate OR expression after infection with SARS-CoV-2.

Marianna Zazhytska, PhD
Zuckerman Institute

GeNETics of COVID-19 induced anosmia

Sandeep Robert Datta, MD, PhD
Harvard Medical School

Determinism in odor receptor choice